The Feds find a naked woman in the middle of the busiest street in NY with tattoos covering her entire body. They take her in for questioning, but Jane (that's what they call her for the lack of a better name) has absolutely no idea who she is and/or what she's doing here. The only thing that she does know is that Weller, an agent with the Bureau, is somehow connected to all this. So, the two start to work together and use the tattoos on her skin to bring the bad guys to justice. The question still remains: why did someone put clues all over her body and erase her memories? Who would want to help the FBI and stay anonymous? Maybe they are using the Bureau for their own needs?